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BRCA Testing

Thousands in the UK carry inherited risks for breast, ovarian, prostate, and pancreatic cancers. BRCA gene screening helps you understand yours early.

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1:400

In the general population is a carrier

According to the NCI.

10x

Ashkenazi Jews carry the mutation at a rate of 1:40

Making the population particularly volnurable to the related cancers.

>70%

Lifetime risk for carriers of BRCA1 for Breast Cancer

For Ovarian cancer the lifetime risk is between 11-17%. For Prostate cancer the risk is 20-25%.

6%

Risk for male breast cancer (400 cases in the UK/year)

As opposed to the general population at <0.1%.

Cancer Type BRCA1 BRCA2 Notes
Breast cancer Very strong link; especially early-onset, triple-negative breast cancer with BRCA1
Ovarian cancer Very strong link
Prostate cancer 🚫 BRCA2 especially raises risk and aggressiveness
Pancreatic cancer ✅ (weaker) ✅ (stronger) Both increase risk, BRCA2 more so
Male breast cancer 🚫 Strongly linked to BRCA2
Melanoma 🚫 ➡️ Slight increase (mainly BRCA2)
Not a major risk, but some studies suggest BRCA2 link
Breast cancer
BRCA1:
BRCA2:
Notes:
Very strong link; especially early-onset, triple-negative breast cancer with BRCA1
Ovarian cancer
BRCA1:
BRCA2:
Notes:
Very strong link
Prostate cancer
BRCA1:
🚫
BRCA2:
Notes:
BRCA2 especially raises risk and aggressiveness
Pancreatic cancer
BRCA1:
✅ (weaker)
BRCA2:
✅ (stronger)
Notes:
Both increase risk, BRCA2 more so
Male breast cancer
BRCA1:
🚫
BRCA2:
Notes:
Strongly linked to BRCA2
Melanoma
BRCA1:
🚫
BRCA2:
➡️
Notes:
Slight increase (mainly BRCA2)
Not a major risk, but some studies suggest BRCA2 link

Table of contents

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Disclaimer! The information provided in this article is for educational purposes only and is based on NHS recommendations. It is not a substitute for professional medical advice. Always consult your doctor or a qualified healthcare provider for advice on medical conditions or treatments.

What are BRCA1 and BRCA2?

BRCA1 and BRCA2 are genes that help repair damaged DNA and keep cells growing normally. Everyone has these genes, but some people inherit changes (mutations) in BRCA1 or BRCA2 that stop them working properly. When this happens, the risk of developing certain cancers, particularly breast, ovarian, prostate, and pancreatic cancers, can increase significantly. BRCA gene screening can help identify if you carry these mutations before symptoms appear.

Inherited BRCA mutations can be passed down from either the mother’s or the father’s side of the family. Knowing if you carry a BRCA1 or BRCA2 mutation can help you take proactive steps to manage your cancer risk, with options for early monitoring, preventative treatments, or lifestyle changes.

Should I Consider BRCA Genetic Testing?

You might want to consider BRCA gene testing if you have a family history of breast, ovarian, prostate, or pancreatic cancer, particularly if relatives were diagnosed at a young age (under 50). If you have multiple close relatives affected, or if there is a known BRCA mutation in your family, testing may provide important information for your health and your family's.

Certain groups, such as people of Ashkenazi Jewish descent, are also at a higher risk of carrying BRCA mutations, around 1 in 40, compared to 1 in 400 in the general population. Overall, carrying a BRCA1 or BRCA2 mutation can mean up to a 70% lifetime risk of breast cancer and up to a 44% risk of ovarian cancer. Understanding your genetic risk can open the door to personalised care and prevention options.

What causes BRCA1 and BRCA2 Mutations?

BRCA mutations are inherited, meaning they are passed down through families. If one of your parents carries a BRCA mutation, there is a 50% chance you could inherit it. While these mutations increase cancer risk, they are relatively rare in the general population.

Testing for BRCA1 and BRCA2 mutations can identify if you have inherited one of these changes. If detected, it allows you and your healthcare team to develop a personalised plan for regular screening, preventative measures, and possible treatments. For those exploring at-home options, we have BRCA gene test kit available throughout the UK to help you begin your genetic health journey from the privacy of your own home.

How is Risk Managed If You Have a BRCA Mutation?

If you test positive for a BRCA mutation, there are many options to help manage your risk. These might include more frequent screening (such as annual mammograms and MRI scans from a younger age), preventative surgeries (like risk-reducing mastectomy or removal of the ovaries and fallopian tubes), and medications that can lower your risk.

Your care team, including genetic counsellors and specialists, will work closely with you to create a personalised plan based on your individual risk and preferences, supporting you every step of the way.

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Type of Cancers

Type of Cancers

Type of Cancers

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Frequently
Asked Questions

How to get tested for BRCA gene?

Getting tested for BRCA1 and BRCA2 is simple and fully supported with Jeen.

You can order your at-home DNA kit online and collect your sample using a quick, painless buccal swab. Your DNA is then analysed in a certified lab using high-depth sequencing to detect BRCA mutations and related cancer risks.

Once your results are ready, you’ll have a one-to-one consultation with a genetic counsellor who’ll explain your risk clearly and help you plan your next steps, all from the comfort of home.

How much does a BRCA gene test cost?

BRCA gene testing with Jeen costs £660. This all-inclusive price covers your at-home DNA kit, lab analysis using 50x high-depth sequencing, and a personalised consultation with one of our expert genetic counsellors.

We don’t just test for BRCA1 and BRCA2, we screen 50 key genes linked to hereditary cancer risk for a more complete picture. There are no hidden fees, just clear, clinically accurate results and expert support to help you take control of your health.

Who should get tested for the BRCA gene?

You should consider BRCA gene testing if you have a personal or family history of breast cancer, ovarian cancer, prostate cancer, or pancreatic cancer, especially if diagnosed under age 50 or in multiple relatives.

It's also recommended if a family member has a known BRCA1 or BRCA2 mutation. Even without a strong family history, testing can uncover hidden inherited risks. At Jeen, we help you understand if testing is right for you through expert counselling and easy, at-home access.

At what age should you be tested for the BRCA gene?

There’s no one-size-fits-all age, which is why our genetic counsellors review your personal and family history to help you decide the right time.

At Jeen, we recommend considering BRCA gene testing from your mid-20s, especially if you have a family history of breast, ovarian, or related cancers. Testing earlier allows you to take proactive steps like enhanced screening or prevention, well before symptoms appear.

How long does it take to get BRCA test results?

With Jeen, BRCA gene test results typically take 3 to 4 weeks from the time your sample reaches our certified lab. During this time, we use high-depth sequencing to analyse 50 key genes linked to hereditary cancer risk, including BRCA1 and BRCA2 for accurate, reliable insights.

Once your results are ready, our expert genetic counsellors will walk you through what they mean and help you plan your next steps with clarity and confidence.

How accurate is the BRCA gene test?

Jeen’s BRCA gene test is built for clinical-grade accuracy. We use 50x DNA sequencing, which reads each gene segment multiple times to detect even rare mutations with high confidence.

Our certified lab provides 99% coverage of both BRCA1 and BRCA2, focusing on meaningful inherited changes, not harmless variants. Every result is reviewed by genetic experts and explained clearly in your personalised consultation, so you get trusted insights and support to guide your next steps.

Where can you get tested for the BRCA gene?

You can get tested for the BRCA gene easily and securely with Jeen, and there is no need to visit the clinic.

We send you a simple at-home buccal swab kit, so you can provide your DNA sample from the comfort of home. Your sample is analysed in a certified USA lab using advanced 50x sequencing for high accuracy.

Once your results are ready, you’ll have a personalised consultation with one of our expert genetic counsellors.

What happens if I test positive for the BRCA gene?

A positive BRCA result means you carry an inherited mutation that increases your risk of certain cancers, most notably breast and ovarian.

Our expert genetic counsellors at Jeen, in partnership with Spital Clinic, will guide you through what this means for your health. This may include enhanced screening, preventive options, or lifestyle changes to help lower your risk. We’ll also support you in sharing this information with your family, so they can make informed choices about their own health too.

Can I get genetic counselling before BRCA testing in London?

Yes, you can access expert genetic counselling in London before starting BRCA testing with Jeen. Our counsellors help you understand what the test looks for, what your results could mean, and how they may impact you or your family. This personalised support gives you the clarity and confidence to decide whether testing is right for you.

Should my family members get tested if I have a BRCA mutation?

Yes, if you test positive for a BRCA mutation, your close family members should consider genetic testing too. Because BRCA mutations are inherited, your parents, siblings, and children may carry the same gene change and face a higher risk of cancers like breast and ovarian.
Early testing helps them take proactive steps, such as enhanced screening or preventive care.

At Jeen, our expert genetic counsellors are here to support you and your family in understanding and navigating these important next steps together.

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Our team of expert Genetic Counsellors is here to help. Whether you're curious about testing, your results, or what’s right for you — we're just a message away.

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