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Endometrial Cancer

Silent but serious, endometrial cancer affects thousands. Genetic testing for endometrial cancer could be your early warning.

Genes Tested:

MLH1
MSH2
MSH6
PMS2
EPCAM
PTEN
POLD1
POLE
TP53
10,000

New cases in the UK every year

Making endometrial cancer the most common gynaecological cancer in the UK

13th

Endometrial cancer is the 13th most common cancer in the UK

Survival rates are above 90%when diagnosed early, and drops to 17% at metastatic stage.

34%

Of endometrial cancer cases are preventable in the UK per CRUK

Mainly due to Lunch Syndrome, a condition that is linked with high risk for certain cancers.

37%

Average lifetime chance of developing endometrial cancer

This is for a women with an MLH1 pathogenic variant

What is Endometrial Cancer?

Endometrial cancer, also known as uterine or womb cancer, occurs when abnormal cells in endometrium grow and divide uncontrollably, forming a tumour. The endometrium is the inner lining of the womb which thickens each month to prepare for pregnancy and is shed during menstruation. Endometrial cancer is most commonly diagnosed after menopause, but it can occur at younger ages too.

Endometrial cancer is a gynaecological cancer, but is distinct from other gynaecological cancers such as ovarian cancer or cervical cancer. Symptoms of endometrial cancer can include:

  • Unusual vaginal bleeding, particularly after menopause
  • Bleeding between periods or unusually heavy periods
  • Pelvic pain or discomfort
  • Pain during sex
  • Unexplained weight loss
  • Fatigue

These symptoms are common to many less serious conditions, but if they are new, persistent, or frequent, it’s important to see a doctor. Early diagnosis can make a big difference to treatment outcomes. If you are experiencing any symptoms that are worrying you, it is important that you report this to your GP.

More information about Endometrial Cancer can be found on the Macmillan website.

What are the causes?

Usually, when someone is diagnosed with cancer, the cause is unknown. Contributing factors may include age, family history, environment, lifestyle and hormonal factors.

In some cases, genetic testing can identify a variant (change) in a single gene that causes a person to have an increased risk of developing certain cancers over their lifetime. These gene variants can be passed down through families.

One cause of inherited endometrial cancer is a condition known as Lynch syndrome, which causes an increased lifetime risk of colorectal cancer, endometrial cancer, ovarian cancer and certain other cancers.

Is genetic testing for endometrial cancer risk genes right for me?

Some people with a personal diagnosis or strong family history of endometrial cancer, or related cancers, such as colorectal cancer or ovarian cancer, may choose to consider genetic testing to try and identify a cause for their diagnosis or their family history.

Identifying a variant in a cancer gene can help clarify personal risk of developing certain cancers and inform your risk management options.

Genetic testing can provide very useful information, but may not be the right choice for everyone. Speaking to a genetic counsellor can help you explore your personal and family history, understand what testing might mean for you and your family, and help you make a decision that feels right for you.

Disclaimer! The information provided in this article is for educational purposes only and is based on NHS recommendations. It is not a substitute for professional medical advice. Always consult your doctor or a qualified healthcare provider for advice on medical conditions or treatments.

Genetic
Counselling

Cancer RiskPanel options

Cancer Risk Screening

Turnaround

17

-

21

days

Genes
50
Book £
660

Breast Cancer Risk Screening

Turnaround

17

-

21

days

Genes
13
Book £
660

Ovarian Cancer Risk Screening

Turnaround

17

-

21

days

Genes
14
Book £
660

BRCA Testing

Turnaround

17

-

21

days

Genes
2
Book £
660

Type of Cancers

Type of Cancers

We offer expert advice and testing for a range of genes that may increase your risk of developing certain types of cancer.

View Full Gene List

What do we test for?

Know your genes, protect your future. Over 5,000 diseases are linked to genetic mutations. Early insights through genetic testing can help with prevention, early detection and personalised healthcare decisions.

Frequently Asked Questions

Does endometrial cancer run in families?

Endometrial cancer can run in families, especially when linked to inherited conditions like Lynch syndrome. Gene mutations passed down through generations can increase your risk, even if no one’s talked about it before.

At Jeen, our at-home genetic test checks for these changes and includes expert genetic counselling to help you understand your personal risk and take proactive steps for early detection and prevention.

How much does genetic testing for endometrial cancer cost in the UK?

Jeen’s genetic testing for endometrial cancer is priced at £660. This all-inclusive cost covers your at-home DNA kit, lab analysis using high-depth 50x sequencing, and a personalised consultation with one of our expert genetic counsellors.

The test analyses 50 carefully chosen genes, each backed by strong scientific evidence linked to prostate cancer risk. You’ll get accurate insights into your inherited risk and support to help you decide on next steps with no extra charges or referrals needed.

Can genetic testing help with endometrial cancer treatment?

Yes, genetic testing can play an important role in shaping endometrial cancer treatment. By identifying inherited mutations in genes, it helps healthcare practitioners better understand the tumour’s biology. This insight can guide more effective treatment options, such as immunotherapy or targeted therapies. It also supports personalised monitoring and prevention, for you and potentially at-risk family members.

Jeen’s at-home genetic test provides accurate results and expert counselling to help guide your next steps with confidence.

If I have a family history of endometrial cancer, should I get tested?

If endometrial cancer runs in your family, genetic testing can uncover inherited risks that may not be obvious. Conditions like Lynch syndrome often involve gene changes that can skip generations or appear without a clear pattern. Even distant relatives’ diagnoses can matter.

At Jeen, our expert genetic counsellors review your full family history and guide you through your options, so you can make informed, confident decisions about your health and future.

What is the difference between hereditary and sporadic endometrial cancer?

Understanding the difference between hereditary and sporadic endometrial cancer can help determine whether genetic testing is right for you. Here’s how they differ: Hereditary endometrial cancer is caused by inherited mutations (like those seen in Lynch syndrome). It often runs in families, appears at a younger age, and may come with risks for other cancers.

Sporadic endometrial cancer happens by chance, without a clear inherited cause. It’s more common and typically occurs later in life with no strong family history. At Jeen, our genetic test helps identify hidden hereditary risk—so you can take proactive steps, even if your family history isn’t clear.

What is included in a genetic test for endometrial cancer?

Jeen’s genetic test for endometrial cancer includes analysis of key genes linked to increased risk, especially those associated with Lynch syndrome, such as MLH1, MSH2, MSH6, and PMS2. Using advanced 50x sequencing, we provide accurate detection of inherited mutations.

The process starts with a simple at-home cheek swab, analysed in a certified lab. You’ll receive a detailed report and a one-to-one consultation with a genetic counsellor to help you understand your results and plan next steps with confidence.

Is there a genetic test for endometrial cancer?

Yes, there is a genetic test that can identify inherited mutations linked to endometrial cancer. It focuses on key DNA repair genes like MLH1, MSH2, MSH6, and PMS2, which are commonly associated with Lynch syndrome, a condition that significantly increases your risk.

Private genetic testing for endometrial cancer in the UK with Jeen offers at-home genetic test screens for these mutations using advanced 50x sequencing, providing accurate results.

You’ll also receive personalised guidance from a genetic counsellor to help you understand your risk and plan for prevention or early detection.

How accurate are genetic tests for endometrial cancer risk?

Jeen’s genetic tests are built for clinical-grade accuracy. We use 50x DNA sequencing, which reads each gene segment multiple times to reliably detect inherited mutations in genes linked to endometrial cancer risk. This high-depth approach reduces errors and ensures clear, precise results.

While no test can predict exactly what will happen, Jeen gives you trusted insights and expert support to make confident, informed health decisions.

Can genetic testing detect other cancer risks along with endometrial cancer?

Jeen screens for 50 carefully selected genes, so you're not just tested for endometrial cancer risk, you’re covered for a wide range of hereditary cancers. Many of these genes are linked to multiple conditions, meaning one simple test can uncover risk for ovarian cancer, colorectal cancer, pancreatic cancer, breast cancer, and more.

Even if your family history isn’t clear, this broad approach gives you a fuller picture of your inherited risk with expert support and a quick at-home buccal swab.

How can endometrial cancer be prevented?

Preventing endometrial cancer starts with understanding your individual risk, especially when genetics may play a role. At Jeen, we believe informed choices begin with clear insights.

Know your family history: If you have relatives with endometrial or related cancers, genetic testing can uncover hidden risks. Jeen tests for 50 clinically relevant genes to give you a comprehensive view.

Maintain a healthy weight: Excess body fat can raise estrogen levels, which increases risk. Balanced nutrition and regular activity help.

Manage hormones wisely: Long-term hormone use should be guided by medical advice.

Personalised screening: Genetic results can inform your doctor about the best way to monitor your health over time.

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Our team of Expert Specialists is here to help. Whether you're curious about testing, your results, or what’s right for you. We're just a message away.

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