Silent but serious, endometrial cancer affects thousands. Genetic testing for endometrial cancer could be your early warning.
Making endometrial cancer the most common gynaecological cancer in the UK
Survival rates are above 90%when diagnosed early, and drops to 17% at metastatic stage.
Mainly due to Lunch Syndrome, a condition that is linked with high risk for certain cancers.
In the UK, the figure is thought to be 1:400, or about 175,000 poeple
Disclaimer! The information provided in this article is for educational purposes only and is based on NHS recommendations. It is not a substitute for professional medical advice. Always consult your doctor or a qualified healthcare provider for advice on medical conditions or treatments.
Endometrial cancer is a disease where abnormal cells in the lining of the womb (endometrium) grow and divide uncontrollably. These cells can form a lump or tumour and may, in some cases, spread to other parts of the body. The endometrium plays a key role in the menstrual cycle and supporting pregnancy.
Most endometrial cancers are a type called endometrioid adenocarcinoma, which starts in the glandular tissue of the endometrium. Endometrial cancer is most commonly diagnosed after menopause, but it can occur at younger ages too. As with many cancers, early detection greatly improves the chances of successful treatment.
If you have a family history of endometrial cancer, or related cancers such as bowel, ovarian, or stomach cancer, you may want to consider genetic testing for endometrial cancer. Inherited changes (mutations) in genes such as MLH1, MSH2, MSH6, and PMS2, associated with Lynch syndrome, can significantly increase the risk of developing endometrial cancer. Genetic testing can help you find out whether you carry one of these mutations, providing important information for your future health and your family’s.
You might be at higher risk if you have two or more close relatives with endometrial or colorectal cancer, if someone in your family was diagnosed at a young age (under 50), or if Lynch syndrome is known in your family. People of Ashkenazi Jewish descent may also carry a higher risk for certain genetic mutations. Around 2-5% of endometrial cancers are thought to be linked to inherited genetic changes. Understanding your genetic risk can open the door to early monitoring, preventative options, and personalised care plans.
Many of these symptoms can be caused by less serious conditions, but if they are persistent or unusual for you, it’s important to see a doctor. Early diagnosis can make a big difference to treatment outcomes.
Endometrial cancer can develop due to a combination of factors, including age, hormonal imbalances (especially too much oestrogen), obesity, diabetes, and family history. In many cases, the exact cause isn’t clear.
Inherited genetic mutations play a role in a small but significant proportion of endometrial cancers. Lynch syndrome, caused by changes in mismatch repair genes like MLH1, MSH2, MSH6, and PMS2, greatly increases the risk. Genetic testing can help detect these inherited risks early, allowing for tailored monitoring, risk-reducing strategies, and early intervention if needed.
Diagnosis usually begins with a pelvic examination and imaging tests like ultrasound. If there are concerns, a biopsy of the endometrium may be performed to check for cancer cells.
If you are concerned about inherited risk, endometrial cancer genetic testing can identify mutations linked to Lynch syndrome and other hereditary conditions. Knowing your genetic status can help you and your healthcare team plan for regular screening and preventative measures to reduce your risk.
Treatment for endometrial cancer depends on the stage, type, and whether the cancer has spread. Most early-stage endometrial cancers are treated with surgery, often involving removal of the womb (hysterectomy) and possibly the ovaries and fallopian tubes. Depending on the cancer’s features, additional treatments such as radiotherapy, chemotherapy, or hormone therapy may be recommended.
For individuals with inherited genetic mutations, treatment decisions may also consider future risk management, including screening for related cancers. Your care team will work closely with you to develop a personalised plan focused on the best possible outcomes while supporting your overall quality of life.
We offer expert advice and testing for a range of genes that may increase your risk of developing certain types of cancer.
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Endometrial cancer can run in families, especially when linked to inherited conditions like Lynch syndrome. Gene mutations passed down through generations can increase your risk, even if no one’s talked about it before.
At Jeen, our at-home genetic test checks for these changes and includes expert genetic counselling to help you understand your personal risk and take proactive steps for early detection and prevention.
Jeen’s genetic testing for endometrial cancer is priced at £660. This all-inclusive cost covers your at-home DNA kit, lab analysis using high-depth 50x sequencing, and a personalised consultation with one of our expert genetic counsellors.
The test analyses 50 carefully chosen genes, each backed by strong scientific evidence linked to prostate cancer risk. You’ll get accurate insights into your inherited risk and support to help you decide on next steps with no extra charges or referrals needed.
Yes, genetic testing can play an important role in shaping endometrial cancer treatment. By identifying inherited mutations in genes, it helps healthcare practitioners better understand the tumour’s biology. This insight can guide more effective treatment options, such as immunotherapy or targeted therapies. It also supports personalised monitoring and prevention, for you and potentially at-risk family members.
Jeen’s at-home genetic test provides accurate results and expert counselling to help guide your next steps with confidence.
If endometrial cancer runs in your family, genetic testing can uncover inherited risks that may not be obvious. Conditions like Lynch syndrome often involve gene changes that can skip generations or appear without a clear pattern. Even distant relatives’ diagnoses can matter.
At Jeen, our expert genetic counsellors review your full family history and guide you through your options, so you can make informed, confident decisions about your health and future.
Understanding the difference between hereditary and sporadic endometrial cancer can help determine whether genetic testing is right for you. Here’s how they differ: Hereditary endometrial cancer is caused by inherited mutations (like those seen in Lynch syndrome). It often runs in families, appears at a younger age, and may come with risks for other cancers.
Sporadic endometrial cancer happens by chance, without a clear inherited cause. It’s more common and typically occurs later in life with no strong family history. At Jeen, our genetic test helps identify hidden hereditary risk—so you can take proactive steps, even if your family history isn’t clear.
Jeen’s genetic test for endometrial cancer includes analysis of key genes linked to increased risk, especially those associated with Lynch syndrome, such as MLH1, MSH2, MSH6, and PMS2. Using advanced 50x sequencing, we provide accurate detection of inherited mutations.
The process starts with a simple at-home cheek swab, analysed in a certified lab. You’ll receive a detailed report and a one-to-one consultation with a genetic counsellor to help you understand your results and plan next steps with confidence.
Yes, there is a genetic test that can identify inherited mutations linked to endometrial cancer. It focuses on key DNA repair genes like MLH1, MSH2, MSH6, and PMS2, which are commonly associated with Lynch syndrome, a condition that significantly increases your risk.
Private genetic testing for endometrial cancer in the UK with Jeen offers at-home genetic test screens for these mutations using advanced 50x sequencing, providing accurate results.
You’ll also receive personalised guidance from a genetic counsellor to help you understand your risk and plan for prevention or early detection.
Jeen’s genetic tests are built for clinical-grade accuracy. We use 50x DNA sequencing, which reads each gene segment multiple times to reliably detect inherited mutations in genes linked to endometrial cancer risk. This high-depth approach reduces errors and ensures clear, precise results.
While no test can predict exactly what will happen, Jeen gives you trusted insights and expert support to make confident, informed health decisions.
Jeen screens for 50 carefully selected genes, so you're not just tested for endometrial cancer risk, you’re covered for a wide range of hereditary cancers. Many of these genes are linked to multiple conditions, meaning one simple test can uncover risk for ovarian cancer, colorectal cancer, pancreatic cancer, breast cancer, and more.
Even if your family history isn’t clear, this broad approach gives you a fuller picture of your inherited risk with expert support and a quick at-home buccal swab.
Preventing endometrial cancer starts with understanding your individual risk, especially when genetics may play a role. At Jeen, we believe informed choices begin with clear insights.
Know your family history: If you have relatives with endometrial or related cancers, genetic testing can uncover hidden risks. Jeen tests for 50 clinically relevant genes to give you a comprehensive view.
Maintain a healthy weight: Excess body fat can raise estrogen levels, which increases risk. Balanced nutrition and regular activity help.
Manage hormones wisely: Long-term hormone use should be guided by medical advice.
Personalised screening: Genetic results can inform your doctor about the best way to monitor your health over time.
Our team of expert Genetic Counsellors is here to help. Whether you're curious about testing, your results, or what’s right for you — we're just a message away.
