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PrenatalSafe Complete Plus NIPT

200+ collection locations across the UKFind your closest

PrenatalSafe Complete Plus, is one of our most advanced non-invasive prenatal test (NIPT), screening for a broader range of chromosomal, genetic  and rare conditions in your baby.

Book PrenatalSafe Complete Plus

conditions checked:

Down syndrome
patau syndrome
edwards' syndrome
Microdeletions
De Novo Mutations
Trustpilot
Trustpilot
Book PrenatalSafe Complete Plus
Medically reviewed by Dr Fred Ushakov, Medical Director & Founder·Last reviewed January 2026
17-21

Working days turnaround time for results, once sample reaches lab.

Fast lab processing means most parents receive their results within a few working days.

£1490

All-inclusive cost

Includes the PrenatalSafe Complete Plus test, analysis, and a consultation with a midwife. Blood collection is not included: arrange your own at no extra cost, or book a partner collection point (+£40) or a home-nurse visit (+£65).

>99%

PrenatalSafe Detection rate for Down’s, Edwards’ and Patau’s syndromes.

Conditions like Trisomy 21, 18, and 13 can occur even without family history. Screening helps identify risk early in pregnancy.

1 in 126*

Pregnancies are affected by the conditions screened by PrenatalSafe Complete Plus.

*This number is based on UK prevalence data for conditions screened by PrenatalSafe Complete Plus.

Table of contents

Jeen
NIPT
PrenatalSafe Complete Plus
Book now £1490

Why choose PrenatalSafe Complete Plus NIPT?

  • Widest screening available: Tests for a full spectrum of chromosomal and genetic conditions, including microdeletions and single-gene disorders.
  • High Accuracy: Detects over 99% of cases of Down’s syndrome (Trisomy 21), with similarly high detection rates for Edwards syndrome (Trisomy 18) and Patau syndrome (Trisomy 13).
  • Safe and Simple: Requires only a single tube of maternal blood; no risk to you or your baby.
  • Quick Results: Results are typically available within 17-21 working days from the time your sample arrives at our partner lab in Italy.
  • Low Failure Rate: Less than 0.5% of tests fail to produce a result, reducing the need for repeat testing.

What conditions does PrenatalSafe Complete Plus screen for?

  • Common trisomies: Down’s syndrome (Trisomy 21), Edwards' syndrome (Trisomy 18) and Patau syndrome (Trisomy 13)
  • Sex chromosome conditions: Turner syndrome, Klinefelter syndrome and Other X/Y chromosomal changes‍
  • 9 microdeletion syndromes, including: DiGeorge syndrome (22q11.2 deletion), Cri-du-chat syndrome, Prader-Willi and Angelman syndromes‍
  • Over 200 single-gene disorders, such as: CHARGE syndrome, Achondroplasia, Osteogenesis imperfecta and it is the only NIPT we offer that screens for Alagille syndrome, Schinzel-Giedion syndrome and Holoprosencephaly.‍
  • Optional Fetal Sex Determination: Know your baby’s sex early, if desired.

Full condition list available on request or during your midwife appointment or genetic counselling session.

How does the PrenatalSafe Complete Plus work?

During pregnancy, small amounts of your baby’s DNA circulate in your bloodstream. PrenatalSafe Complete Plus uses whole-genome sequencing and targeted analysis to detect a wide range of chromosomal and genetic changes. It’s completely non-invasive and safe for both you and your baby.

Who Should Consider PrenatalSafe Complete Plus?

This test is suitable for any expectant parent who wants the most comprehensive genetic screening available. It’s especially recommended if:

  • You’re seeking a wider reassurance about your baby’s health.
  • You have a family history of genetic conditions or previous pregnancy loss.
  • You’re looking to avoid invasive procedures like amniocentesis.
  • You want to know more than what standard NIPTs offer.

PrenatalSafe Complete Plus can also be used in certain twin pregnancies, including cases where a vanishing twin has been identified. In these situations, DNA from the demised twin can remain in the bloodstream for many weeks, so timing of the test and careful interpretation of results are important. A higher-risk result may reflect the vanishing twin rather than the ongoing pregnancy, and may need repeat testing or genetic counselling to confirm. PrenatalSafe Complete Plus may also be suitable for pregnancies using donor eggs or surrogacy.

Get peace of mind early in your pregnancy with the most advanced prenatal screening available in the UK.

What Are My Blood Draw Options for PrenatalSafe Complete Plus NIPT?

In line with our flexible, prevention-first approach, Jeen Health offers multiple convenient options for how you provide your DNA sample for PrenatalSafe Complete Plus NIPT:

  1. Self-Arranged Blood Draw (Free): We'll send your PrenatalSafe Complete Plus NIPT kit and you can then arrange your own blood draw with a local nurse, midwife, phlebotomy service, or clinic. Many patients ask their private GP, or maternity care provider to assist. Please ensure your provider is comfortable drawing into the NIPT-specific tubes supplied in your kit. If needed, we can share instructions.
    • Best if you already have a provider you trust
    • No added charge from Jeen, but you may need to pay your chosen provider directly
    • Nationwide availability across the UK and some EU region
  2. ‍Jeen Clinic Network (+£40): Prefer a clinic-based option? Book a blood draw appointment at one of our 40+ trusted partner locations across the UK.‍‍
    1. Clinics in major cities including Brighton, Cambridge, London, Manchester, Birmingham, Leeds, Newcastle, Edinburgh, Bristol, Cardiff, and Belfast.
    2. Quick and easy appointments, often near transport hub
  3. ‍Home Visit (+£65): Need maximum convenience? We’ll send a qualified nurse to your home to take your blood sample.
    1. Ideal for patients with mobility, time or privacy needs
    2. Available across most of the UK and appointments coordinated by our team

These sample collection options ensure NIPT is accessible on your terms, you choose what’s easiest and most comfortable. No matter where you live, you can pick the collection method that suits you best.

Disclaimer! The information provided in this article is for educational purposes only and is based on NHS recommendations. It is not a substitute for professional medical advice. Always consult your doctor or a qualified healthcare provider for advice on medical conditions or treatments.

Comparison Table

Basic and advanced PrenatalSafe options compared to help you choose the right test for your pregnancy.

Niptify NIPT Comparison

Condition Niptify Focus Plus PrenatalSafe Panorama AI KNOVA
Test Performance & Logistics
Gestational Age Requirement ≥10 weeks ≥10 weeks ≥9 weeks ≥10 weeks
Turnaround Time (working days) 5-10 working days 2-5 working days 7-10 working days 7-10 working days
Lab Location Estonia (EU) UK USA USA
No-Call / Redraw Rate 0.6% 0.5–2% 1–3% 0–1.5%
Standard Chromosomal Conditions
Trisomy 21 (Down's Syndrome) ✔ ✔ ✔ ✔
Trisomy 18 (Edwards' Syndrome) ✔ ✔ ✔ ✔
Trisomy 13 (Patau's Syndrome) ✔ ✔ ✔ ✔
Fetal Sex Determination (Optional) ✔ ✔ ✔ ✔
Core Conditions
DiGeorge Syndrome (22q11.2 Deletion) ✔ – ✔ ✔
Turner Syndrome (45,X) ✔ – ✔ ✔
Sex Chromosome Aneuploidies ✔ – ✔ ✔
Additional Chromosomes ✔ – – ✔
Triploidy – – ✔ –
Microdeletions
Prader–Willi / Angelman Syndrome ✔ – – ✔
Williams–Beuren Syndrome ✔ – – ✔
1p36 Deletion Syndrome ✔ – ✔ ✔
Cri-du-Chat Syndrome ✔ – ✔ ✔
Wolf–Hirschhorn Syndrome ✔ – – ✔
Jacobsen Syndrome ✔ – – ✔
Langer–Giedion Syndrome ✔ – – –
Duchenne Muscular Dystrophy ✔ – – –
Smith–Magenis Syndrome ✔ – – ✔
15q11-q13 Duplication Syndrome ✔ – – –
Neurofibromatosis Type 1 ✔ – – –
Koolen–De Vries Syndrome ✔ – – ✔
Phelan–McDermid Syndrome ✔ – – ✔
Miller–Dieker Syndrome ✔ – – –
Pallister–Killian Syndrome ✔ – – –
3q29 Deletion Syndrome ✔ – – –
2q31.2 Deletion Syndrome ✔ – – –
15q24 Deletion Syndrome ✔ – – –
17q12 Deletion Syndrome ✔ – – –
7q11.23 Duplication Syndrome ✔ – – –
Genome-wide CNVs (>1 Mb) ✔ – – –
Total Microdeletions Screened 20+ genome-wide – 1 12
Unique Features
De Novo Genetic Syndromes ✔ – – 56 genes
Mitochondrial DNA Mutations ✔ – – –
Pregnancy Suitability
Twin Pregnancies – ✔ ✔ (excl. 22q del) –
Vanishing Twin Syndrome ✔ ✔ – –
Donor Eggs / Surrogacy ✔ ✔ ✔ (excl. 22q del) –
Special Features: Niptify is the only NIPT available through Jeen that combines whole-genome sequencing with Focus Plus fetal DNA enrichment technology. It screens for 20+ microdeletion syndromes, genome-wide CNVs larger than 1 Mb, and mitochondrial DNA mutations linked to hearing loss. Niptify is not suitable for donor egg or surrogacy pregnancies, but it maintains reliable performance in pregnancies with higher maternal BMI.

Summary: Niptify Focus Plus offers the most comprehensive genome-wide prenatal screening available, covering common trisomies, 20+ microdeletion syndromes, rare chromosomal conditions and mitochondrial DNA mutations from as early as 10 weeks.

All NIPT options

Aneuploidy NIPT

Aneuploidy NIPT

Non-invasive prenatal screen from 9 weeks. 3 conditions.

From £295
PrenatalSafe 3 UK

PrenatalSafe 3 UK

Non-invasive prenatal screen from 10 weeks. 3 conditions, 2-4 working days from when your sample reaches the laboratory.

From £325
Panorama NIPT

Panorama NIPT

Non-invasive prenatal screen from 9 weeks. 9 conditions, 7-10 working day turnaround.

From £355
Panorama Microdeletions

Panorama Microdeletions

Non-invasive prenatal screen from 9 weeks with microdeletions. 13 conditions, 7-10 working days.

From £525
Niptify NIPT

Niptify NIPT

Non-invasive prenatal screen from 10 weeks. 30 conditions, 5-10 working day turnaround.

From £525
Unity Complete Screen

Unity Complete Screen

Non-invasive prenatal screen from 9 weeks. 12 conditions, 17-21 working day turnaround.

From £800
KNOVA

KNOVA

One of our most advanced non-invasive prenatal tests, screening for a broader range of chromosomal, genetic and rare conditions in your baby - including microdeletions and many monogenic disorders.

From £950

20 Minute Midwife Counselling

Get started

Frequently Asked Questions

What’s the difference between basic and advanced NIPT?

Basic NIPT screens for the three most common chromosomal conditions: Down’s syndrome (Trisomy 21), Edwards’ syndrome (Trisomy 18), and Patau’s syndrome (Trisomy 13). Advanced NIPT includes everything in the basic test, but can also check for sex chromosome conditions, some rare genetic deletions (called microdeletions), and can tell you the biological sex of the baby if you choose to know. At Jeen, our NIPT specialists will help you decide which version is right for you during your consultation.

Why do I need to send my scan before doing the NIPT?

We ask you to send us your pregnancy scan so our medical team can confirm that you’re at least 9/10 weeks pregnant (depending on the test you’ve chosen) and that the pregnancy appears to be developing as expected. By reviewing a recent scan performed within one week of your NIPT blood draw, our doctors can check that there are no early concerns before going ahead with your NIPT.

It’s also helpful to know that NIPT screens for specific genetic conditions only. It doesn’t look for physical or structural differences, such as heart defects or organ development issues, which are usually identified later in pregnancy through detailed ultrasound scans. Reviewing your early scan helps ensure NIPT is appropriate for you before moving forward.

Can I do NIPT at home?

Yes. At Jeen Health, the standard option is for you to arrange your blood test at home independently. If you prefer, we can organise your blood test for you for an additional fee.

Can NIPT tell me the sex of my baby?

Yes, NIPT can identify the baby’s biological sex with high accuracy, but this is completely optional. If you’d like to know, just let our team know during your consultation and if you’d rather not find out, we’ll make sure it’s not included in your report.

Is NIPT covered by the NHS?

At the moment, NIPT is only offered on the NHS in certain situations, such as when a standard screening test shows a higher chance of a genetic condition. At Jeen, we offer private NIPT testing with flexible options, fast results, and full clinical support, including expert guidance and convenient at-home appointments.

How long do PrenatalSafe Complete Plus NIPT results take?

Your results will usually be ready within 17–21 working days from the time your sample arrives at our partner lab in Italy. Once the results arrive our admin team will call and deliver the results to you as soon as they’re ready.

Please note that delays can occur during public holidays in both the UK and Europe. If your results indicate that follow-up testing is needed for your partner, we’ll act quickly to keep everything moving smoothly. Our priority is to get you the answers you need without unnecessary delays, so you can make confident, informed decisions for your pregnancy.

When can I take the NIPT and is it safe?

NIPT is completely safe for both you and your baby. It’s a non-invasive blood test that requires only a small sample from your arm and involves no physical contact with the baby. This means there’s no risk of miscarriage or harm to the pregnancy, unlike invasive diagnostic procedures. You can take the PrenatalSafe Complete Plus NIPT from 10 weeks into your pregnancy.

Before booking your test with Jeen, we’ll ask you to upload a recent pregnancy scan (such as a dating or viability scan). This allows our specialist medical team to confirm that the test is suitable for you before proceeding.

If you’re looking for earlier testing options, you may wish to consider Panorama NIPT or Unity Complete NIPT, which can be taken earlier in pregnancy depending on individual circumstances.

How accurate is NIPT?

NIPT is over 99% accurate at detecting Down’s syndrome and is also highly reliable for Edwards’ and Patau’s syndromes. It is more accurate than standard NHS screening and produces fewer false-positive results, meaning fewer people are referred for unnecessary follow-up testing.

Visit our NIPT statistics page for more information.

Do I need midwife counselling before NIPT?

Yes. With Jeen, you must attend an online midwife NIPT counselling appointment before the test. After this appointment, we will send you the kit for sample collection.

At Jeen, we believe it’s important that everyone taking NIPT has the chance to speak to a qualified midwife (or a genetic counsellor for an additional fee) first. This session helps you understand what the test covers, what it doesn’t, and what the results might mean for you and your baby. It’s also a space to ask questions and make confident, informed choices.

What happens if my NIPT result is high risk?

If your result shows a high risk for a condition, we’ll arrange a follow-up session with one of our genetic counsellors to explain exactly what it means. You’ll be given the option to have a diagnostic test, such as amniocentesis or CVS, which can confirm the result. We’ll support you at every step, with clear information and no pressure.

Will NIPT detect all possible conditions?

PrenatalSafe Complete Plus is an advanced NIPT that builds on the PrenatalSafe 3 UK panel, which screens only for the three common trisomies: Down’s syndrome (Trisomy 21), Edwards’ syndrome (Trisomy 18) and Patau syndrome (Trisomy 13).

In addition to these, PrenatalSafe Complete Plus also screens for Sex chromosome conditions, such as Turner syndrome, Klinefelter syndrome and other X/Y chromosome variations. 9 microdeletion syndromes, including DiGeorge syndrome (22q11.2 deletion), Cri-du-chat syndrome, Prader-Willi syndrome and Angelman syndrome. As well as, selected de novo single-gene conditions, including achondroplasia, osteogenesis imperfecta, Rett syndrome, CHARGE syndrome, Cornelia de Lange syndrome, Sotos syndrome and others

Like all NIPT tests, PrenatalSafe Complete Plus does not screen for physical or structural differences (such as heart or organ development issues), which are usually detected through ultrasound scans.If you’re considering other advanced NIPT options, we also offer KNOVA and Panorama with microdeletions. The most suitable test for you will be discussed during your midwife consultation and may depend on your medical history, scan findings and individual needs.

‍Can I change my NIPT after booking?

Yes. You can change your NIPT option following your counselling or midwife appointment. If you decide to switch to a less expensive test, we will issue a refund for the price difference within 5–10 working days.
‍
If you choose to upgrade to a more advanced or higher-priced NIPT option, we will invoice you for the additional amount after your consultation.

Our midwife will help you choose the most appropriate test based on your medical history, scan findings, and personal preferences, ensuring you have the right screening option for your pregnancy.

Please note: If you upgrade your test, your NIPT kit will not be sent until the additional invoice has been paid in full.

Explore more

  • all NIPT tests compared
  • standard PrenatalSafe NIPT
  • Unity Complete inherited screen
  • KNOVA genome-wide NIPT
  • aneuploidies T21/18/13
  • microdeletion syndromes

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