Genetic Disease Risk

No - and we’d rather be upfront about that. Polygenic scoring is more strongly validated for some conditions (coronary artery disease, breast cancer, type 2 diabetes, lipoprotein(a)) than others, and accuracy also varies with your genetic ancestry.

Most published polygenic scores were developed mainly from European-ancestry data and become less accurate for other backgrounds. Our models (via Allelica) are ancestry-specific, for a better-calibrated score across diverse heritages.

No referral is needed - anyone aged 18+ can order directly. This private test does not replace the NHS screening programmes you’re entitled to.

No. A PRS estimates inherited risk only. It is not a diagnosis, not a prediction that you will or won’t develop a condition, and not a replacement for NHS screening.

It scores your inherited risk across 21 common conditions from a single saliva sample - including coronary artery disease, stroke, atrial fibrillation, type 2 diabetes, raised cholesterol, several common cancers (breast, prostate, bowel, ovarian, pancreatic and melanoma), Alzheimer’s disease and osteoporosis. Each is reported as your polygenic risk compared with the rest of the population.

Single-gene tests such as BRCA or carrier screening look for rare, high-impact mutations in one gene. A polygenic risk score (PRS) instead adds up thousands of common genetic variants across your whole genome to estimate your risk of common, complex diseases. The two are complementary - a PRS measures the everyday genetic background that single-gene panels are not designed to capture.

The test is £299, which includes your at-home saliva kit, laboratory analysis across all 21 conditions, a personalised report and a consultation with a genetic counsellor, included in the price. You can spread the cost with three interest-free Klarna payments of £99.67 at checkout.

Results are usually ready about four weeks after the laboratory receives your saliva sample. A genetic counsellor reviews every report and explains it in plain English, with onward referrals if anything needs follow-up.

A higher polygenic risk score is not a diagnosis - it means prevention may matter more for you. Your genetic counsellor will talk you through practical next steps, which might include lifestyle changes, earlier or more frequent screening, or a conversation with your GP. Knowing sooner gives you and your doctor more time to act.